If you don’t have a brother or sister and there is no close match in your family, you may have what is know as a Match Unrelated Donor transplant (MUD transplant), where the donor is not related to you. A brother or sister is most likely to be a close match to you. The cells from the donor have to closely match your cells, this is tested using HLA typing or tissue typing. The stem cells can be from your own blood, known as autologous stem cell transplant, or they can be from someone else, an allogeneic transplant. Stem cells are then transplanted back through a drip into the body to start making blood cells again. The transplantation of bone marrow, peripheral blood or cord blood stem cells, involves chemotherapy to kill off the bone marrow cells including the cancerous cells. The treatment of the blood cancer may require a stem cell transplant to be carried out. However, much work remains to be done in the laboratory and the clinic to understand how to use these cells for cell-based therapies to treat disease, which is also referred to as regenerative or reparative medicine Transplantation of stem cells Given their unique regenerative abilities, blood stem cells offer new potentials for treating diseases such as diabetes, and heart disease. The stem cells from the donor have to be a close match to the recipient. What are autologous and allogeneic stem cell transplants?Īutologous stem-cell transplantation is the transplantation in which stem cells are removed from a person, stored, and later given back to that same person after a high dose of chemotherapy.Īllogenic stem cell transplantation is where the donor and the recipient of the stem cells are different people.
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